About Us

Company

Manfred Schmolz, PhD, founded his first company "Experimental & Diagnostic Immunology GmbH" (EDI GmbH) in 1996 as a contract research and development lab. In 2000 EDI GmbH was certified according to ISO 13485. The goal was to establish complex Co-Culture systems (nowadays: HOT Co-Culture models) for improved in vitro drug activity profiling, thereby circumventing the usually poor translational value of more simple cell culture systems, such as those using isolated immune cells. The invention of the TruCulture® System filled another gap between pre-clinical and clinical immunopharmacology. In September 2007 EDI GmbH merged with Rules-Based Medicine, USA, and in 2014 EDI GmbH became HOT Screen GmbH, after a Management Buy-Out from Myriad-RBM. HOT Screen offers not only contract research in the field of immunopharmacology, immunotoxicology and cell biology, but also contract development of customized cell culture systems, including TruCulture®, of which >100 different types have been designed during the past two decades. HOT Screen services are offered to pharma, biotech, cosmetic, food supplement companies and medical device manufacturers. Our cell culture systems can be designed for pharmacological, toxicological or biocompatibility investigations, the latter even for testing solid materials. HOT Screen provides more than 25 years of experience with a wide spectrum of samples, such as complex natural preparations, small molecules, biologicals, probiotic bacteria, implantable materials, etc.

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History/Facts

• Founded: 1996 as EDI GmbH (fully financed by contract research from the start)
• Purpose: Contract research for pharma, food supplement, biotech, and medical device companies
• Technology: Innovative „organotypic“ test systems, focusing on the complexity of the human immune system with its numerous links to organ physiology
• 25+ years of experience with a wide spectrum of samples: homeopathic, complex natural extracts, small molecules, biotech products, biologicals, probiotic bacteria, semi-solid and solid test samples, etc.
• 1999: Invention of the TruCulture® system
• 2000: Certification according to ISO 13485 (Medical Device Directive)
• 2007: EDI GmbH merged with Rules-Based Medicine, USA
• 2014: Management Buy-out, continuing to offer the same spectrum of services with the same highly experienced team, but now under “HOT Screen GmbH”
• Exclusive manufacturer & custom developer of TruCulture® for RBM
• 2014: Certification according to ISO 9001