HOT systems are used for screening as well as in-depth profiling of compounds for bioactivity (drugs, nutraceuticals, food supplements, probiotics, cosmetics, as well as surface modifications of dialysis membranes, implant materials, etc.).
Primary goal of HOT Screen is to provide services and test systems for the investigation of not only single compounds, but also complex mixtures / final formulations (creams, ointments, suppositories, etc.) under in vivo-like conditions. This was achieved by establishing different types of culture models, particularly co-culture systems comprising various cells types from different organs as well as cells of the human immune system in a co-operative fashion.
All cellular tests can be performed to target immunopharmacological or immunotoxicological activities of the test substances in question.