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"For this purpose HOT Screen offers a series of proprietary, complex (Human Organo-Typic: "HOT") cell culture models, developed during the past two decades. Each of these consists of cells of a specific organ of interest (gut, lung, skin, etc.) with immune cells, the latter in the form of whole blood cultures. All of these models allow the investigation of drug effects under a whole variety of conditions. Enabling the test substances to affect the extensive cross-talk between all different cells in these co-cultures (tissue as well as immune cells) provides a deeper insight into not only the primary core activities of drugs, but also reveals otherwise hidden, often secondary effects. This increases the translational value of such investigations substantially. By choosing thoroughly different activating conditions it is possible to modify the testing conditions, to simulate pathogenetically relevant situations.

A major part of drug activities is their absorption by outer or inner body surfaces. This aspect of drug activities is covered by co-culture systems combining human whole blood cultures with differentiated human intestinal or bronchial epithelia, or 3D human epidermis. As also absorption can be modulated in vivo by local inflammation, these co-culture models can be adapted to mimic such conditions and therefore expand drug R&D options already in vitro.