Cell culture services
Contract research and development for functional characterization of immuno-biologically active substances and materials
The human immune system is regulated by a complex network of signals between various cell types. The combination of cell types, structures, and interactions must be preserved in any testing model to accurately assess the effects an investigational product may have on the human immune system. To provide researchers with reliable in vitro testing models throughout the development continuum, HOT Screen GmbH offers highly standardized, yet complex cell culture solutions for in vivo-like substance characterization and profiling, called Human OrganotypicalTest (HOT) Systems.
What HOT Screen offers
- Immuno-pharmacological and immuno-toxicological characterization, primarily in highly standardized complex human cell culture models
- Contract development of customized cellular and non-cellular test systems, e.g. bioassays for quality control of recombinant proteins
- Consulting services around clinical trials for immunologically active drugs (anti-inflammatory, immuno-suppressive, immuno-potentiating, etc.)
- Moreover, we provide more than 20 years of extensive experience in the critical testing of complex biological materials (natural products, such as herbal extracts, probiotics, etc.)
» Plain whole blood cultures from healthy donors or patients
» Complex, multi-layered cell cultures (HOT Co-diabetes, HOT Co-Lung, HOT Co-Skin, HOT Co-Gut, HOT Co-Joint, HOT Co-vein)
» Numerous types of cell culture models available to match various pathophysiological conditions or modes of action
» A closed whole blood collection and culture system.
The translational value of HOT models
See data below illustrating the translational relevance of the combined use of such models.
Download the Poster
All HOT Screen Culture Systems are for Research Use Only. Not for use in diagnostic procedures.
Whole Blood and HOT Co-Culture services are performed by expert cell and tissue culture scientists and technicians at HOT Screen GmbH, Reutlingen, Germany, where these proprietary drug profiling systems were developed and have been successfully employed for more than 15 years.
Combine these testing models with our Multi-Analyte Profiling (MAP) services for a comprehensive mediator analysis.