Whole Blood Cultures
If you can’t avoid complexity, make it your friend - immunopharmacology and immunotoxicology tested in one stroke
The human immune system – a complex network
The functionality of the human immune system is based on an intricate network of positive and negative feedback signals between the different leukocyte (sub-)sets. Each of these cell types secretes and reacts to a wide variety of messenger substances (cytokines, chemokines, lipid mediators, radicalized substances, amongst others).
Why Whole Blood Cultures?
Only cell culture models that represent the full spectrum of immune cells can provide sufficient insights into the immunopharmacological and immunotoxicological activity profiles of a drug in vivo. This is why human whole blood is used in HOT culture and co-culture models whenever possible. Regardless of the mechanism of action of immunobiologically active compounds, such complex models readily reveal a far more complete spectrum of drug activity than any other test system.
Knowing such effects of newly developed drugs enables a precise definition, often even an extension, of their potential clinical applications. Substances exhibiting doubtful effects may be eliminated from the R&D pipeline at an early stage or modified chemically to achieve the desired safety. The use of HOT Screen test models can accelerate the substance development process considerably.
Whole blood cultures, when combined with a careful selection of endpoint measurement systems, represent the best available tool for optimized compound profiling.
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