Publications
Published research projects
HOT Solids - Material Testing
A Human Whole Blood Culture System Reveals Detailed Cytokine Release Profiles of Implant Materials (2024)
Sascha Niclas Klimosch, Marbod Weber, Jordi Caballé-Serrano, Thomas Knorpp, Antonio Munar-Frau, Birgit Margareta Schaefer, Manfred Schmolz
An Innovative, Centrifugation-free Method to Prepare Human Platelet Mediator Concentrates Showing Activities Comparable to Platelet-rich Plasma (2011)
Manfred Schmolz, Gerburg M. Stein, Wolf-Dietrich Hübner
HOT Co-Culture
Characterization of immunologically active drugs in a novel organotypic co-culture model of the human gut and whole blood (2012)
Michael Schmohl, Nicole Schneiderhan-Marra, Nadja Baur, Kathrin Hefner, Michael Blum, Gerburg M. Stein, Thomas O. Joos, Manfred Schmolz
Functional drug candidate profiling using complex human organotypic cell culture models: a promising way to reduce clinical drug failure (2007)
Manfred Schmolz
TruCulture®
HOT Screen and Rules Based Medicine have a long-standing partnership to advance multidisciplinary research with the TruCulture® system.
View the seeding TruCulture publication and selected publications of TruCulture® customers below or get an overview of all TruCulture®-based research articles.
Functional Analysis via Standardized Whole-Blood Stimulation Systems Defines the Boundaries of a Healthy Immune Response to Complex Stimuli (2014)
Darragh Duffy, Vincent Rouilly, Valentina Libri, Milena Hasan, Benoit Beitz, Mikael David, Alejandra Urrutia, Aurelie Bisiaux, Samuel T. LaBrie, Annick Dubois, Ivo G. Boneca, Cecile Delval, Stephanie Thomas, Lars Rogge, Manfred Schmolz, Lluis Quintana-Murci, and Matthew L. Albert
Smoking changes adaptive immunity with persistent effects (2024)
Violaine Saint-André, Bruno Charbit, Anne Biton, Vincent Rouilly, Céline Possémé, Anthony Bertrand, Maxime Rotival, Jacob Bergstedt, Etienne Patin, Matthew L. Albert, Lluis Quintana-Murci, Darragh Duffy & The Milieu Intérieur Consortium
Safety and immunogenicity of SARS-CoV-2 recombinant protein vaccine formulations in healthy adults: interim results of a randomised, placebo-controlled, phase 1–2, dose-ranging study (2021)
Paul A Goepfert, Bo Fu, Anne-Laure Chabanon, Matthew I Bonaparte, Matthew G Davis, Brandon J Essink, Ian Frank, Owen Haney, Helene Janosczyk, Michael C Keefer, Marguerite Koutsoukos, Murray A Kimmel, Roger Masotti, Stephen J Savarino, Lode Schuerman, Howard Schwartz, Lawrence D Sher, Jon Smith, Fernanda Tavares-Da-Silva, Sanjay Gurunathan, Carlos A DiazGranados, Guy de Bruyn
Preoperative TruCulture® whole blood cytokine response predicts post-operative inflammation in pancreaticoduodenectomy patients—A pilot cohort study (2020)
Eske K. Aasvang, Sandra Pitter, Carsten P. Hansen, Jan H. Storkholm, Paul S. Krohn, Stefan K. Burgdorf, Jakob H. Von Stemann, Jens D. Lundgren, Susanne D. Nielsen, Henrik Kehlet, Sisse R. Ostrowski
Immune profiling in M. tuberculosis infection enables stratification of patients with active disease (2020)
Darragh Duffy, Elisa Nemes, Alba Llibre, Vincent Rouilly, Elizabeth Filander, Hadn Africa, Simbarashe Mabwe, Lungisa Jaxa, Bruno Charbit, Munyaradzi Musvosvi, Humphrey Mulenga, the Milieu Intérieur Consortium, Stephanie Thomas, Mark Hatherill, Nicole Bilek, Thomas J Scriba, Matthew L Albert
Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques (2019)
Joaquín Sanz, Paul L. Maurizio, Noah Snyder-Mackler, Luis B. Barreiro
Standardized whole blood stimulation improves immunomonitoring of induced immune responses in multi-center study (2017)
Darragh Duffy, Vincent Rouilly, Cecile Braudeau, Véronique Corbière, Raouf Djebali, Marie-Noelle Ungeheuer, Regis Josien, Samuel T. LaBrie, Olivier Lantz, Delphine Louis, Eva Martinez-Caceres, Francoise Mascart, Jose G. Ruiz de Morales, Catherine Ottone, Lydia Redjah, Nina Salabert-Le Guen, Alain Savenay, Manfred Schmolz, Antoine Toubert, Matthew L. Albert
Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses (2017)
Alejandra Urrutia, Darragh Duffy, Vincent Rouilly, Céline Posseme, Raouf Djebali, Gabriel Illanes, Valentina Libri, Benoit Albaud, David Gentien, Barbara Piasecka, Milena Hasan, Magnus Fontes, Lluis Quintana-Murci, Matthew L. Albert